INDUCTION OF MITOTIC CROSSING OVER IN SACCHAROMYCES CEREVISIAE BY BREAKDOWN PRODUCTS OF DIMETHYLNITROSAMINE, DIETHYLNITROSAMINE, 1-NAPHTHYLAMINE AND 2-NAPHTHYLAMINE FORMED BY AN IN VITRO HYDROXYLATION SYSTEM
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چکیده
منابع مشابه
Induction of Mitotic Crossing over in Saccharomyces Cereviszae by Breakdown Products of Dimethylnitros- Amine, Diethylnitrosamine, I-naphthylamine and 2-naphthylamine Formed by an in Vitro Hydroxylation System
Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise l-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown products which are then the proximately active agents, and microorganisms lack the ...
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ژورنال
عنوان ژورنال: Genetics
سال: 1973
ISSN: 1943-2631
DOI: 10.1093/genetics/74.3.433